The model of combination of diseases with differentiation of syndromes has a disease name in modern medicine, and adopts treatment principles and methods from traditional Chinese medicine (TCM). It is a new model of combination of TCM and modern medicine. The clinical effect assessment with doctors' experiences of TCM is unable to be accepted internationally. Therefore, it hinders TCM development. However, to adopt standards of modern medicine is unable to reflect advantages of TCM. TCM effect assessment is based on the model of combination of diseases with differentiation of syndromes. It is an integrated method of combining objective effect with subjective effect. This model also combines short term effect with long-term effect. Hence, this model will better reflect the effectiveness and authenticity of TCM.