Mesoscopic Simulation Study on Influencing Factors on Micellization of Ginsenoside Ro
人参皂苷Ro胶束化影响因素的介观模拟研究

To get a deep understanding of influencing factors of preparation on micellization of ginsenoside Ro(Ro), mesoscopic simulation had been employed to study the critical micelle concentration (CMC) and morphology changes of Ro with different temperature, concentrations of insoluble drug and salt strength. The results indicate that the CMC of Ro is about 1.29 vol% at room temperature. High temperature tends to inhibit the micellization of Ro and makes higher CMC and longer time for Ro to aggregate. However, the insoluble drug SSa can facilitate the micellization process because the hydrophobic cores formed by SSa molecules induce the aggregation of Ro. The salt strength has little effect on the CMC of Ro.