Establishment of Screening Platform for Medicines Resistant to Vascular Diseases Caused by Diabetes with RAGE as Their Target
建立以RAGE为药靶的抗糖尿病血管病变药物的筛选平台

晚期糖基化终产物（advanced glycation end-products,AGEs）受体（receptor for advanced glycation end-products,RAGE）在糖尿病血管病变的发生发展过程中具有相当重要的作用, 可作为防治糖尿病血管病变的药物靶点。建立以RAGE为药靶的体内外筛药系统,用于中药提取物的筛选,将显著提高中药抗糖尿病血管病变有效成分的筛选效率及准确性,对于阐明中药治疗糖尿病血管病变的机制,加快中药现代化进程有重大意义。