Explore the Action Patterns and Mechanisms of Traditional Chinese Medicine Incompatibility of Qi-Qing Antagonism and Mutual Inhibition/Restraint based on Drug Interaction
基于药物相互作用探讨中药七情合和相反/相恶/相畏配伍禁忌作用模式与机制

This paper proposed three kinds of action patterns of traditional Chinese medicine (TCM) incompatibility based on the cognitions for theories of seven ways of compatibility and drug interaction. These are toxication and potentiation toxicity action pattern embodied the characteristic of antagonism, efficiency reduction and decrease effect action pattern reflected the characteristic of mutual inhibition/restraint, and toxic-effect multiple action pattern embodied the complex characteristics of antagonism and mutual inhibition/restraint. In addition, we exploringly put forward eight possible mechanisms of TCM incompatibility. They are potentiation toxicity by promoting the release of toxic substances, potentiation toxicity by producing new toxic components, potentiation toxicity because of increased toxic components resulted from mutual transformation of chemical constituents, efficiency reduction through inhibiting the dissolving of active components, efficiency reduction through inactivating the active components, toxication resulted by toxic metabolite generated in vivo based on drug interaction, adverse effects caused by affecting the physiological disposition of incompatibility combinations, and adverse effects caused by regulating and controlling the drug metabolic enzymes. Furthermore, the authors discussed the correlations between the different action patterns and mechanisms and relationships of seven ways of compatibility. These opinions would be providing references for understanding and researching the essences of TCM incompatibility.