From Traditional Decoction to Modern Granule: Perspectives and Prospects of Chinese Medicine Dispensing Granules
从汤剂到颗粒剂:中药配方颗粒20年回顾与展望

In the present paper, the chemical analysis, clinic, pharmacology, quality control and production process of Chinese medicine dispensing granule in the past two decades were reviewed. The emphases of this paper are paid on the equivalence between single dispensing granule and mixed decoction and quality control of dispensing granule. The equivalence research data has certain reference value for manufacture, quality control and clinical application of dispensing granule. The Chromatography is suitable techinique used for quality control of dispensing granule. The advanced technology and process about dynamic extraction, concentration technology, freezing drying and one-step granulation has been used in production of dispensing granule. The equivalence between single dispensing granule and mixed decoction needs further systematic and deep scientific research. The quality control standard should reflect the integrated quality of dispensing granule. The scientific selection of the method is the key for quality control of dispensing granule. To ensure the quality consistency of dispensing granule, the quality control method based on "holistic" components analysis should be established, the concentrating ratio for dispensing granule should be calculated, and the production process of dispensing granule should be standardized.