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OALib Journal期刊
ISSN: 2333-9721
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Screening and Mechanism Study of Natural Products and Derivatives for Prevention and Cure of Neurodegenerative Diseases by Taking Microglia Activation as the Target
以抑制小胶质细胞活化为靶标的抗神经退行性疾病的天然产物及衍生物的筛选与机制研究

Keywords: 神经退行性疾病,小胶质细胞,MAPK/NF-κB,信号通路,人参皂苷,姜黄素,白藜芦醇

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Abstract:

Microglia activation is associated with the occurrence and progression of neurodegenerative diseases. Thus, inhibition of microglial activation is generally considered a useful strategy for treatment of many neurodegenerative diseases. This paper reviews our research progress in the inhibitory effects of natural products including resveratrol, curcumin, resveratrol derivatives, curcumin derivatives and ginsenosides on microglia activation. This may provide a reference for the further exploration in this field.

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