Effect of Eerdun-Wurili on Rabbit Atherosclerosis Recession and Inflammation Factors
额尔敦-乌日勒在家兔动脉粥样硬化斑块消退中的作用及其对炎症因子的影响

The study is aimed to observe the effect of Eerdun-wurili on atherosclerosis recession.Related inflammation factors were detected in the mechanism discussion.High cholesterol feeding method was used in the rabbit atherosclerosis model establishment.Eerdun-wurili was used in a 12-week treatment.Content of serum total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HLD-C),and serum inflammatory markers hypersensitive C-reactive protein(hs-PCR) were detected after the experiment.Level of vascular cellular adhesive molecular-1(VCAM-1) was also tested.The aortic atherosclerosis severity was observed.The VCAM-1 mRNA expression level in the aorta was also observed.The results showed that compared with natural recession group,level of serum TC,TG,LDL-C in the treatment group were reduced.The content change of HLD-C was not significant.The percentage of aortic plaque area in total area and the ratio between inner-membrane and tunica media were also decreased.Serum hs-PCR content and VCAM-1 level were reduced.VCAM-1mRNA aortic expression level was also declined.It is concluded that Eerdun-wurili plays a recession role in early atherosclerosis.Its mechanism may be related to cholesterol-lowering and anti-inflammation.