Oxidative Damage Induced by Lanthanum, Cerium and Neodymium in Liver Nuclei of Mice
镧、铈、钕对小鼠肝细胞核的氧化损伤作用

Light rare earth elements are found to mainly accumulate in the livers of receiving organisms. They can enter into hepatocytes and are mainly distributed in the nuclei. To investigate the oxidative damage effects of light rare earth elements on the hepatocyte nuclei isolated from the mouse liver, five-week-old male ICR (imprinting control region) mice were exposed to lanthanum (La), cerium (Ce) and neodymium (Nd) by oral gavage for 6 weeks with different doses, i.e., 10, 20 and 40 mg·kg-1. The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were determined as well as the contents of glutathione (GSH) and malondialdehyde (MDA). ANOVA analysis of the results showed that compared with the control group, GPx activity and MDA content in every exposure group increased (p<0.05); except in the Ce low-dosage group, SOD and CAT activities in other exposure groups decreased (p<0.05) in a dose-dependent manner; except in the La low-dosage, Ce low-dosage and Ce middle-dosage groups, GSH content in other exposure groups increased (p<0.05). It is indicated that La, Ce and Nd could induce oxidative damage in hepatic nuclei of mice.