THE RELATIONS OF GENE EXPRESSION LEVEL AND SYNONYMOUS CODON USAGE
基因表达水平与同义密码子使用关系的初步研究

We propse a self-consistal information clustering method to predict gene expression leveland synonymous codon usage. The codons are xlassified into three kinds: optimal codons.non-optimal codons and rare codons. We consider that gene expression level are controlledmainly by the usage frequencies of these three kinds of codons. On the basis of this viewpoint,for E. coli 121 genes and Yeast 107 genes, we predict the gene expression level and synonymous codon usage by the self-consistent information dustering method. It is found thatgenes for each species can be classified into four distinct groups. very high-expressed genesVH). high-expressed genes(H). moderate-expressed gene(LM) and low expressed genes(LL).The results of gene expression level and synonymous codon usage are consistent with experimental data.