Review of Systems Biology Approach to Study on Developmental Toxicity Mechanism of Environmental Pollutants
环境污染物发育毒性机制研究的系统生物学方法进展

Gene regulatory network (GRN) was a novel systematical biology approach for the study on gene regulation mechanism, especially helpful in describing the early development of animal body. Because GRNs can present the networks and dynamics of regulatory processing, and the true impacts from the environmental perturbation, they were expected to play a key role in studying developmental toxicity mechanisms of environmental pollutants including endocrine disrupting chemicals with resolving many problems which existed for a long time. The structures, methodologies, current application cases of GRNs are rewiewed. The application of GRNs into mechanism researches of developmental toxicity of pollutants is previewed in this paper.