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生态毒理学报 2012
Methods of Inhibiting Cadmium Toxicity and Its Mechanism: A Review
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Abstract:
Cadmium (Cd) is easily accumulated in humans but difficult to be discharged by organism itself. Since the accumulated Cd causes serious effects on human health, it is very important to investigate the methods and mechanisms of inhibiting Cd toxicity. In this paper, inhibiting Cd toxicity by chelator, metallothionein, nutrient elements (zinc, selenium, calcium, iron and vitamins), and Chinese traditional medicine was summarized. The corresponding inhibition mechanisms were discussed and reviewed. Until now, many measurements for inhibiting Cd toxicity all utilize some additive substances with higher affinity to Cd so as to form some easily-discharged complexes which can be removed out of animal body through its normal physiological activities. Therefore, the interference of Cd with normal metabolic activities of necessary elements was eliminated. The mechanisms of inhibiting Cd toxicity by Chinese traditional medicine might be a promising research area.