RADIOSENSITIVE EFFECT OF MISONIDAZOLE-IRISQUINONE ON MAMMALIAN CELLS IN VITRO
Misonidazole—马蔺子甲素对哺乳动物细胞的辐射增敏作用

Miso (misonidazole) is a very efficient sensitizer both in vitro and in vivo. Neverthelss, Clinical application of Miso is ultimately limited by its neurotoxicity. Recently, Many research has tended to concentrate on two aspects aiming either at decreasing its neurotoxic properties or increasing the sensitizing efficiency.Irisquinone was used as hypoxic radiosensitizer and modificatory agent to reduce cytotoxicity of Miso in our experiment .Chinese hamaster cells(CHO) was treated with 0.5 mM Miso and 0.05 mM Irisquinone in combination. Then treated CHO cells were exposed to X-rays under aerobic and hypoxic conditions. Experimental results show that hypoxic cells toxicity can be modified by Irisquinone and that in above conditions the abserved enhancement ratio is 1.27, which approaches the data of 1.29 when 1mM Miso is used only.