ARTERIAL REMODELING BY THE CHANGES OF WALL SHEAR STRESS IN VIVO
壁剪应力变化对动脉重建影响的在体研究

To explore the changes of wall shear stress(WSS) effect on arterial remodeling after reducing arterial flow, the reducing flow model was established in 60 rabbits. The following detections were carried out at 8 different time intervals from 0 to 30 days: wall thickness, lumen diameter, arterial endothelial cell(AEC) and smooth muscle cell density. Decreased arterial diameter may be correlated with vasomotion modulated by the changes of WSS. There was no significant difference both in the ratio of wall thickness/lumen diameter(WT/LD) and the numbers of smooth muscle cells comparing with that of control. The density of AEC was affected by the changes of WSS, which decreased significantly at 3 and 7days, and increased at 14 and 30 days(p<0.01). The results suggested that WSS influences arterial remodeling by regulating its vasomotion and not changing WT/LD. The changes of WSS may play an important role in AEC remodeling.