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生物物理学报 2002
IN VIVO WHOLE-CELL RECORDING TECHNIQUE AND ITS APPLICATION
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Abstract:
In vivo whole-cell recording technique can be used not on ly to study the properties of re-sponse to natural stimulus in sensory system, such as light for visual system and sound for auditory sys-t em, but also to study the mechanism of sensory information processing, because a cell's synaptic poten-tial, including subthreshold response, can be recorded accurately, and the cell's EPSPs and IPSPs can be s eparated relatively. This technique, including how to choose some major instruments, is described in de-tail. The results illustrate its appl ication in visual system and somatosensory system. The prospect of thi s technique in neuroscience is also discussed.