Identification of H2A.Z and H2A nucleosomes based on histone methylation information
基于组蛋白甲基化信息的H2A.Z和H2A核小体识别

H2A.Z, the variant of H2A, plays a crucial role in the process of gene expression. Based on the different patterns of histone methylation between H2A.Z and H2A nucleosomes, the method of Increment of Diversity with Quadratic Discriminant (IDQD) was successfully applied to the classification of H2A.Z and H2A nucleosomes. The results demonstrated the effectiveness of the IDQD model. By computing sequence flexibility, the average flexibility of DNA wrapped around the H2A.Z nucleosome was found to be significantly smaller than that around the H2A.Z nucleosome.