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生物物理学报 2002
SLOW WAVE OSCILLATION INDUCED BY VERATRIDINE IN INJURED DORSAL ROOT GANGLION NEURONS
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Abstract:
In order to study relationship between inactive gate of sodium channel and patterns of discharges from injured dorsal root ganglion, spontaneous activities from single fibers of chronically compressed dorsal root ganglion neurons were recorded. We observed and analyzed patterns and characters of slow wave oscillation of interspike interval (ISI) recorded from injured dorsal root gaglion neuron fibers induced by veratridine, a blocker of inactive gate of sodium channel. It is suggested that the basic characters of slow wave oscillation in injured dorsal root ganglion have large varied amplitude and long cyclic duration, and that it can be divided into five basic patterns i.e.V type, reversal Π type, integer multiple type, diffusive type and compound type.