PREDICTION OF SECONDARY STRUCTURE FOR MACROMOLECULE RNAs
RNA大分子的二极结构预测

A computer method is preseted for predicting the secondary structure of maeromolecule RNAs with the minimal free energy.It is based on the maximum C-matching brineiple of topological planar graph and avaliable thcrmodvnamie data of folding a single-stranded nucleic aeid molecules.In order to illustrate the predicting power of our algorithm, an immunoglobulin heavy chain mRNA fragment(159residues) ,E.coli 165 rRNA fragment(567-883).and poliovirus RNA fragment(1-7.10)are folded . and their seeondary structure models are constru-eted.Meanwhile,these models are compared with their available structure models, and the results are discussed. The seeondary structural model of the central domain of E.coli. 16S rRNA predicted by computer showes good agreement with that of Noller and woese.