PROTECTIVE EFFECT OF TWEEN-80 MICELLE ON GROUND AND EXCITED STATES OF PERYLENEQUINONOID PHOTOSENSITIZERS
Tween-80胶束对苝醌类光敏剂基态和激发态的保护作用

In this work, hypocrellins A and B (HA, HB), and hypericin (HYP) were dispersed in Tween-80 micelle. It was found that the micelle had protective effect on ground state and excited state of HA. Compared with HA in water-contained organic solvents, the pigment in micelle had higher pKa value and higher fluorescence quantum yield. Moreover, the quantum yield of active species produced from photosensitization, 1O2 and ·OH, increased as well. As a result, the photosensitivity of HA was enhanced. The protective effect of Tween-80 micelle on HB and HYP was similar to that on HA, and the protective effect was related to the molecular structures of perylenequinonoid photosensitizers. This provided information for screening better photosensitizers for photodynamical therapy.