Evaluation of the Thickness of the Nanometer-sized Ultrasound Contrast Agents Microbubble Shell Using a Novel Ultra High Speed Camera Combined with Ultrasound Backscatter
基于超高速摄影显微成像和超声散射的纳米包膜造影微泡包膜厚度估计

Motivated by the need to measure the thickness of ultrasound contrast agent microbubble shell generally of nanometer scale,which is of great value in the structure analysis and mechanics parameters evaluation on microbubble, a novel ultra high speed digital camera capable of 100 million frames/s was used to capture the radial fluctuations of a bubble during insonation. By comparison of the predicted radial oscillations with those measured optically, the thickness of the shell can be evaluated in Root-Mean-Square sense. It is envisioned that the use of the new technique will expand to find its way in the target drug encapsulation and delivery as well as ultrasound contrast imaging methods.