An analysis of neural information within electrogenic hippocampal epileptic network in rats
电刺激诱导大鼠海马癫痫电网络神经信息分析

The present work was to detect the modulation of scopolamine on characteristics of neural information of electrogenic hippocampal epileptic network in rats. Experiments were performed on 45 SD male rats, weighting 150~250g. The hippocampal epilepsy was induced by the acute tetanization(60Hz, 2s, 0.4~0.6mA) of the right dorsal hippocampus (ATPDH). The ipsilateral hippocampal field potentials and single unit discharges were simultaneously recorded. The power spectrum, power/time of the hippocampal ripples (up to 150 Hz), the interpeak intervals (IPI), of continual robust sharp waves, and the interspike intervals (ISI) of single neuronal firing were analyzed for extracting temporal code information of hippocampal network epilepsy. The result demonstrated that (1) Ripples and continual sharp waves were evoked by the repetitive ATPDH. (2) Scopolamine (0.05 mg/kg, i.p.) shortened the occurrence time of the maximal power spectra (μV2) during the first ripple component and of the maximal ISI of single neuronal firing, but remarkably shortened the latter. (3) A parallel development of robust sharp wave IPI and neuronal firing ISI reappeared partially after the injection of scopolamine, which was induced by repetitive ATPDH trains. It suggested that the temporal coding information of the member fields and neurons could be modulated by the scopolamine simultaneously within hippocampal epileptic network. Both the ripple power spectra and the IPI scatter of hippocampal network could be matched with single neuronal firing ISI scatter for extracting temporal code information.