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生物物理学报 2009
Predicting Membrane Protein Types Using The Random Forests Algorithm
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Abstract:
There is a close relationship between the function and types of membrane proteins, so the prediction of membrane protein types is an important means in the research of protein function, and it has significance to predict the membrane protein types from the protein amino acid sequence. Based on the amino-acid sequence in protein, eight types of membrane proteins were predicted by using the algorithm of random forests with the increment of diversity and the pseudo amino acid composition information. The overall prediction accuracy was 93.8% for independent test and 86.3% for jackknife test respectively, better than results of previous prediction.