|
生物工程学报 2009
Large-scale production of recombinant adeno-associated virus (rAAV)
|
Abstract:
Recombinant adeno-associated virus has been proven to be a promising gene delivery vector for human gene therapy with many advantages.Successful applications of recombinant adeno-associated virus vectors in preclinical and clinical human gene therapies make it become a demanded product.A well-established and large-scale production system is therefore required.Since wild type of adeno-associated virus was well characterized in 1989,progress has been made.Particularly,package system of recombinant adeno-assoc...