Coculture of actinomycetes with Bacillus subtilis and its effect on the bioactive secondary metabolites
放线菌与枯草芽孢杆菌的共培养及其对活性次生代谢产物的影响

To explore the effect of coculturing actinomycetes with Bacillus subtilis on the production of bioactive secondary metabolites,we studied the difference between fermentation products of monocultures and the corresponding cocultures of 22 actinomycetes by antimicrobial assay and HPLC-PDA analysis.We selected Streptomyces strain FXJ2.014 with high bioactivity for further analysis and found additional metabolites in fermentation extracts of cocultures of strains FXJ2.014,FXJ1.296 and AS 4.1252 respectively wit...