THE INFLUENCE OF CHITOSAN AND POLYLYSINERELATED MATERIALS ON NERVE CELLS
多聚赖氨酸改性壳聚糖对神经细胞的作用

Chitosan is a biodegradable material with excellent biocompatibility. This study is to explore the ability of several chitosan related materials to promote the growth of nerve cells. Nerve cells including fetal mouse cerebral cortex cells and gliosarcoma cells were cultured on these materials. In addition, the wettability of these materials and the adsorption amount of extracellular matrix adhesion molecules on all these materials were measured to study the cell behavior of nerve cells on materials. Results showed that chitosan could greatly promote nerve cell growth, and that polylysine coated chitosan and chitosan-polylysine mixture, two better materials in promoting nerve cell growth than chitosan, are promising materials for nerve repairing.