Signal Propagation in Cultured Neonatal Rat Cardiac Myocytes: Multi-electrode Recording Study
培养新生大鼠心肌细胞的电信号传导：多电极记录研究

The signal propagation in cultured neonatal rat cardiac myocytes has been investigated to determine signal propagation patterns when the cells were spontaneously beating or being stimulated. Extracellular recordings of the population action potentials of cardiac myocytes clusters were made using multi-electrode array (MEA). MEA simultaneously recorded electrical activities from various cells and provided information about the number of pacemaker cells, action potential propagation velocity and route, and interactions between different pacemakers. The experiments revealed that the activation of pacemakers and the signal propagation were both affected by the under-threshold stimuli.