THE EFFECT OF SO2 DERIVATIVES ON TRANSIENT OUTWARD K+ CURRENT IN ACUTELY DISSOCIATED RAT HIPPOCAMPAL CA3 NEURONS
二氧化硫衍生物对大鼠海马CA3区神经元瞬间外向钾电流的影响

In order to study the effect of SO2 derivatives -NaHSO3 and Na2SO3 (1:3) on transient outward K+ current in freshly dissociated hippocampal neurons of rats, with the whole cell patch clamp technique, IA was isolated based on the kinetics and pharmacological properties, and the increase effects of SO2 derivatives on IA were investigated in rat acutely isolated CA3 neurons. SO2 derivatives reversibly increased the amplitudes of IA in a concentration-dependent and voltage-dependent, but not frequency-dependent manner. Half-increase dose on IA was 25 μmol/L. 10 μmol/L SO2 derivatives did not affect the activation process of IA, while affected the inaction process rose, the half-inactivation of IA voltages and delayed the process of IA inactiration. It was found that SO2 derivatives increase the amplitude of IA in CA3 neurons, and inhibit the inactivation of IA. After SO2 derivatives application, normal sensory physiology of hippocampal neurons was affected. This variation caused by SO2 could underlie the toxical modulation of sensory input to the central nervous system.