DARPP-32, DOPAMINERGIC PATHWAY AND NEURONAL INFORMATION INTEGRATING
DARPP-32、多巴胺系统与神经元信息整合

DARPP-32 is a kind of protein that is expressed in neostriatal and other nuclei. This protein is important in regulating and integrating many inputs. When Dopamine, glutamate or some other neurotransmitters binds to their receptors, the phosphorylation or dephosphorylation of DARPP-32 occur at 34-Thr or other three sites affects the activitions of phospholipase 1 or 2B, hence all the signals accepted from any pathways can be integrated and the functions of the neuron and behaviors it controlled will be changed. The functions of DARPP-32 are related with many neurotransmitters and their receptors; and it can be studied using 'gene knockout' technique.