THE INFLUENCE OF CHITOSAN AND ITS MODIFIED MATERIALS ON MARROW STROMAL CELLS
壳聚糖及其改性材料对骨髓基质细胞的作用

Chitosan is a kind of widely used biodegradable materials. In order to explore the ability of several chitosan related materials to promote the growth and differentiation of marrow stromal cells, marrow stromal cells were cultured and induced into osteoblasts on these materials. By observing and investigating the growth and differentiation of the cells on these materials, the affinity of these materials for marrow stromal cells were evaluated. In addition, the wettability of these materials and the adsorption amount of extracellular matrix molecules on all these materials were measured to study the cell behav-iors of marrow stromal cells. Results showed that although chitosan did not have very good affinity for marrow stromal cells, the biocompatibility of chitosan was apparently enhanced after mixing with gelatin. The mixture of chitosan and gelatin is a promising material for bone repairing.