EXPRESSION OF SURFACE ADHESION PROTEINS ON CULTURED VASCULAR ENDOTHELIAL CELLS IN SUDDEN-EXPENSION FLOW CHAMBER
突然扩张流槽中血管内皮细胞表面粘附蛋白表达的研究

The non-random distribution of atherosclerosis was related to local hemodynamic environment. Parallel plate rectangle and sudden-expansion flow chamber were constructed in our studies and the flow characteristics in these chambers were analyzed using finite-volume models. The effect of flow pattern on expression of surface adhesion proteins on cultured HUVEC was studied. It was shown that at the same entrance Re number or the mean shear stress condition, the expression of ICAM-1 was higher in sudden-expansion flow chamber than in rectangle flow chamber. There was no effect on E-Selectin expression. In conclusion, the spatial characteristic of fluid flow would influence local function of vascular endothelial cells.