BIFURCATION AND CHAOS IN THE SPONTANEOUSLY BEATING RHYTHM OF CULTURED CARDIAC MYOCYTES
心肌细胞自发性搏动节律的分岔和混沌现象

Heart has the properties of a nonlinear oscillator network consisting of different oscillators and can generate complex beating rhythms. There are many causes responsible for the complexity of rhythm. In order to investigate the spontaneously beating rhythms of cultured cardiac myocytes without external stimulation, different patterns of endogenous rhythms in cardiac myocytes were displayed and a novel phenomena was found that the structure of period doubling bifurcation, as well as chaos series occurred in synchronous transition of rhythm while conductance of myocytes was decreased by heptanol. It was suggested that complex patterns of endogenous rhythm can been generated in synchronously beating cardiac myocytes directly and coupling strengths is one of the important cardiac controlling parameters.