THE EFFECTS OF THE MECHANICAL STRAIN ON THE ADHESION ANDPROJECTIVE AREA AND VISCO-ELASTICITY OF OSTEOBLAST
拉伸作用对成骨细胞粘附、铺展、粘弹性的影响

A four point bending setup was employed to study the response of culture osteoblasts' morphology, adhesion force between the cells and attached surface, and the cellular deformability to mechanical stretch. The osteoblasts from young rats were cultured on a flexible board which might be bent so that the cells were stretched. The morphological parameters were obtained using a microscope-image system. The adhesion force and deformability of the cells was measured by micropipette-aspirating system. The results were shown as follows:(1) After stretched for two hours, the adhesion force and adhesion force per unit area are higher than control group, but no distinct change was observed if stretched for more hours as compared with control.(2) Visco-elasticity of the osteoblast is lower than the control group.(3) The proliferation of the cells is faster than the control after stretched for 24 hours.