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生物物理学报 1996
THE EFFECT OF CHOLESTEROL ON THE STRUCTURE OF DPPC MULTILAYERS
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Abstract:
The effect of cholesterol on the stryctyre of dipalmitoylphosphatidyl-choline(DPPC)multilayers has been studied by SAXD(small angle x-ray diffraction) and DSC(differential scanning calorimetry)techniques. DSC thermograms showed that the sharp,highly cooperative phase transition in DPPC disappeared gradually with increasing of the cholesterol content.At a cholesterol concentration of 40(mol)% or more,a phase separation was observed in both x-ray diffraction and DSC experiment.