A COMPUTERIZED CYTOMECHNICAL ANALYZER OF DYNAMIC PHOTOMETRY TO STUDY THE EFFECTS OF DRUGS ON RBC MEMBRANES
微机化动态光度法细胞力学分析仪研究药物对红细胞膜的作用

This article reported a new computerized cytomechanical analyzer with dynamic shear stress genrator and photometric apparatus which could automatically determine the RBC resting shape parameter (RF) , membrane stiffness parameter (S), relaxation half time (t50%) and cell viscosity parameter (VP) to describe mechanical behaviour for cells. It was carried out to test the sensitivity, accuracy and reproducibility for analyzer, and to study the effects on mechanical behaviour of RBC membranes caused by Triton, Sodium Salicylate, Trental, Dusordril and Rokan (EGb 761). Our results show the important values for our analyzer to study pharmacological effects for drugs and to test cytorheological behaviour in clinical medical investigations.