Metabolic Calculation of the Growth Phase in rHSA Fermentation
重组人血清白蛋白发酵过程生长期的代谢计算

The model equations of the growth phase of rHSA fermentation were derived on the base of both elemental balance and metabolic balance. The unknown parameters of the model were estimated by multivariable optimization. The model can preferably describe the relations between different macroscopic reaction rates of the process and provide the key for the high-density cultivation of Pichia pastoris.