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生物工程学报 2000
Studies of the Mechanism of 7-epi-taxol Converted to Taxol from Taxus Extract Catalyzed with Al2O3
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Abstract:
Under the catalysis of Al 2O 3,7 epi taxol in Taxus yunnanensis extract could convert to taxol.The factors including the concentration of CH 3OH in the mobile phase,the type of Al 2O 3 and the reaction time could influence the isomeric reaction.The catalysis mechanism fo Al 2O 3 was investigated.The isomerization of 7 epi taxol was under the cooperation of the Lewis souci activity core and the basic activity core in the surface of Al 2O 3 at room temperature.The type and strength of activity core controlled the procedure of reaction,and the suitable content of CH 3OH in the mobile phase would accelerate the reaction.
