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生物工程学报 1994
The Pseudohomogeneous Kinetic Models of Production Phase in the Fermentation Process for Producing Undecane Dicarboxylic Acid and Their Application
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Abstract:
The metabolic characters of production phase in the fermentation of unde-cane dicarboxylic acid were analyzed. The kinetic models of cell growth, product formation and substrate consumption in production phase were established respectively. The parameters of the models have been estimated by regression. The calculated curves fit the experimental date quite well and the average deviation between those over production phase is 3. 6%. Based on the kinetic models, computer simulations of production phase were fulfilled. From the computer simulations, it can be seen that the product formation rate could be increased markedly by the following ways: increasing cell concentration before switching into production phase, decreasing the peroid of cell growth phase and lowering the product concentration of production phase.