The Kinetic Models of Cell Growth Phase in the Fermentation Process for Producing Undecane Dicarboxylic Acid and Their Applications
十三碳二元酸发酵过程菌体生长期动力学模型及其应用

The fermentation process for producing undecane dicarboxylic acid from tridecane is introduced. The metabolic characters of cell growth phase in the process were analyzed. It was proposed that cell growth can be indentified by the carbon dioxide production rate (CPR). The best time for switching into production phase can be decided on-line with CPR. The kinetic models of cell growth phase were established and parameters of the models have been estimated by regression. The calculated curves fit the experimental date quite well. The average deviation between those over cell growth phase is 2. 4%. Based on the kinetic models, computer simulations for several technological conditions of cell growth phase were fulfilled. From the results of the computer simulations, it can be seen that cell concentration at the end of cell growth-phase could be increased markedly by increasing both sucrose concentration and initial cell concentration.