It is known that RNA editing occurs in human cells, which can change the information transmission from DNA to RNA and proteins. Most previous studies have focused on editing of the mRNAs. Here we reported that several kinds of RNAs, including miRNA, rRNA, mRNA, miscRNA and unknown RNA, exhibited base editing in a human fetal liver. Several editing types are displayed. Our data reveals that RNA editing may occur in different species of RNAs.
References
[1]
Bass, B.L. (2002) RNA editing by adenosine deaminases that act on RNA. Annual Review of Biochemistry, 71, 817-846.
doi:10.1146/annurev.biochem.71.110601.135501
[2]
Maas, S., Rich, A. and Nishikura, K. (2003) A-to-I RNA editing: Recent news and residual mysteries. Journal of Biological Chemistry, 278, 1391-1394.
doi:10.1074/jbc.R200025200
[3]
Daniel, J.L., Henry, M., Nicholas J.V. and Stefan, M. (2004). RNA editing of a miRNA precursor. RNA, 10, 1174-1177. doi:10.1261/rna.7350304
[4]
Morse, D.P., Aruscavage, P.J. and Bass, B.L. (2002) RNA hairpins in noncoding regions of human brain and Caenorhabditis elegans mRNA are edited by adenosine deaminases that act on RNA. Proceedings of the National Academy of Sciences, 99, 7906-7911.
[5]
Rueter, S.M., Dawson, T.R. and Emeson, R.B. (1999) Regulation of alternative splicing by RNA editing. Nature, 399, 75-80. doi:10.1038/19992
[6]
Li, M.L., Isabel, X.W., Yun, L., et al. (2011) Wide spread RNA and DNA sequence differences in the human transcriptome. Science, 333, 53-58.
doi:10.1126/science.1207018
[7]
Heale, B.S., Keegan, L.P., McGurk, L., et al. (2009) Editing independent effects of ADARs on the miRNA/ siRNA pathways. EMBO Journal, 28, 3145-3146.
doi:10.1038/emboj.2009.244
