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生物物理学报 2003
SIMULATION STUDY ON MODELS FOR MECHANISMS UNDERLYING EEG OF SLOW WAVE SLEEP STAGE 2
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Abstract:
According to the recent physiological theories and the experiment results about slow wave sleep (SWS) mechanisms, it is thought that there exist three different rhythms in the neurons of cortex-thalamic system: slow oscillation (<1 Hz), delta oscillation (1-4 Hz) and spindle oscillation (7-14 Hz). The widespread synchronization of these neurons in cortex level will generate SWS electroencephalograms (EEGs). Three circuit models which can generate the three rhythms respectively are suggested; then they were combined and simplified into a seven-cell circuit model. Moreover the network model composed of many identical circuits can generate waveforms consistent with SWS EEG stage 2. The results reveal the concordance between the physiological experiments about sleep mechanisms and recordings from human natural sleep EEGs; also they enlighten us the chief courses of information processing in which the microscopic, electrical activities of neurons can be integrated into the macroscopic, functional states of human brain.