A STUDY OF MATHEMATICAL MODEL FORINOSITOL-1.4.5-TRIPHOSPHATE-INDUCED Ca~(2+) OSCILLATIONS
三磷酸肌醇影响钙释放的数学模型研究

This article mainly illustrates the character of Ca2 release in the model of agonist-stimulated Ca2 oscillations. The model assumes that IP3(inositol-1.4.5-triphosphate)-receptor/Ca2 -channel consists of three independent subunit which may bind to IP3, activate or inhibit Ca2 release. The prolate model can explain oscillation in many kinds of cells. When the IP3 concentration remains stable, by varying intracellular Ca2 level, the bell shape curve of the open probability of IP3-receptor/Ca2 -channel could be observed. The frequency and amplitude of Ca2 are in close ship with maximum Ca2 dependent IP3 rate(v6). When Ca2 oscillations are sensitive to v6, the relation between the amplitude of Ca2 and v6 can be represented as a straight line approximately.