EFFECT OF GABAergic INHIBITION ON PROPERTIES OF AC NEURONS IN RESPONSE TO SOUND STIMULATION
γ-氨基丁酸能抑制对大棕蝠听皮层神经元声反应特性的影响

In order to determine the effect of GABAergic inhibition on the discharge patterns and properties of AC neurons in response to sound stimulation, we studied the responses of 8 big brown bats (Eptesics fuscus) induced by sound stimulation before and after GABAergic inhibition eliminated by bicuculline application. In the present study, we observed that GABAergic inhibition can change both the discharge pattern of response elicited by sound stimulation, intensity-rate and -latency functions, increase the firing rates of cortical neurons greatly, shorten the latencies, and decrease the minimum threshold. These results demonstrated: 1. GABAergic inhibition plays an important role in sound signal processing of AC neurons. 2. GABAergic inhibition could modify effect of the excitatory innervation or input projecting to AC neurons, and determine the response properties of AC neurons, such as discharge patterns, minimum threshold, rate- and latency-intensity functions; 3. GABNAergic inhibition could present a modulated-inhibition for AC neurons's activity evoked by sound stimulation.