Genomic analysis to fully understand the virulence of uropathogenic Escherichia coli CFT073
致病性大肠杆菌UPEC CFT073全基因组分析及致病机制的新认识

Uropathogenic Escherichia coli (UPEC) strain CFT073 was sequenced with the complete genome and published in 2002. However, the state-of-the-art genomic studies on CFT073 are not yet satisfactory, largely due to the systematic errors and being outdated with the current gene annotation in public database. In this paper, the authors carried out a systematic re-annotation by combining a series of bioinformatics tools and manual efforts to provide a comprehensive understanding of virulence for the CFT073 genome. The re-annotation results in corrections, modifications and supplements to both protein-coding genes and RNA-coding genes. Based on the re-annotation, a group of new virulence factor candidates was listed. Further analysis demonstrated that the present work may facilitate an accurate and comprehensive depiction of virulence mechanisms of the CFT073 strain.