THE SECRETION OF PGI2 AND ET-1 IN T-BIFURCATION FLOW CHAMBER
T型分叉流槽中前列环素和内皮素分泌的研究

The non-random distribution of atherosclerosis was related to local hemodynamic environment. Using the mended parallel plate flow apparatus, such as the parallel plate rectangle and T-bifurcation flow chamber, and reciprocating syringe pump providing fluid flow, endothelial culture models were established in vitro with the same environment factors as steady culture. A numerical calculation procedure based on the finite volume method was employed to simulate flow fields in both flow chambers. The effect of flow pattern on vasoactive mediators secretion was studied. It was shown that at the same entrance Re number, the secretion of PGI 2 was decreased and the secretion of ET-1 was significantly decreased in T-Bifurcation flow chamber compared to uniform laminar shear stress in rectangle flow chamber during 8 h flow period. In conclusion, the spatial distribution of fluid shear stress influenced the local secretion of vasoactive mediators, such as PGI 2 and ET-1.