APPLICATION OF BIOINFORMATICS TO GENE CHIP
生物信息学在基因芯片中的应用

Bioinformatics and gene chip are two new technologies in the field of Life Science. Bioinformatics is very important to the research and the application of gene chip. It plays a key role in gene chip design, experiment data analysis and data management. The applications of Bioinformatics to gene chip are discussed in this paper in great detail. Some rules for designing gene chip are proposed. A new approach for gene chip design, by which an optimal set of oligonucleotide probes can be generated using dynamic programming, is also proposed. The probes have nearly the same melting temperature Tm, and are of variable length and variable overlap. The method is applied to designing gene chips for DNA resequencing, mutational analysis and gene expression analysis. Two software systems, one for gene chip design and one for data analysis have been developed.