A Cellular Automata Model for Simulating Fed-batch Penicillin Fermentation Process
模拟青霉素分批补料发酵过程的细胞自动机模型

Based on a hyphal differentiation and penicillin production structured kinetic model, according to the growth mechanism of penicillin production bacteria and the characteristic of penicillin fed-batch fermentation, a cellular automata model for simulating penicillin fed-batch fermentation process (CAPFM) was established. CAPFM adopted three-dimensional cellular automata as its growth space and adopted Moore type neighborhood as its cell neighborhood. The transition rules of CAPFM were designed based on the mechanism and structured kinetic model of penicillin fed-batch fermentation process. Every cell of CAPFM represented a single or specific number of penicillin production bacteria, and they had various states. The simulation experimental results showed that CAPFM replicates the evolution behaviour of penicillin fed-batch fermentation process described by penicillin production structured kinetic model accordantly. Finally, the application problem of CAPFM in practical production processes is analyzed, and the future study problems are pointed out.