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生物物理学报 1994
STUDY OF DNA DAMACE INDUCED BY LIPOSOME PEROXIDATION
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Abstract:
DNA damage induced by lipopsome perexidation studied by perexidation and DNAdamage de sncously. The adults shoal that during liposome peroxhation, thehyperehrofority of DNA following thenn Odenaturation, sensibility of DNA to DNase I digeStion, conthe of double-sound DNA and fluo infinity of DNA-EBcomplex dec with moor of reaction theing the four usual bases, guanine wasdamage most seriously than the others. Studies of DNA damage induced by liposomeperoxidation in the pothri of various active oxygen quencheIS shoal that hydroxyl radicalsand singlet oxygen produced in the pro of liposome peroxidation were probably boortantfactors tO DNA damage.