Therapeutic Effect of Progesterone on Experimental Peripheral Nerve Injury

This study aims to investigate the therapeutic effect of progesterone on experimental peripheral nerve injury. Methods: A total of 20 male Albino rats weighing 250-300 g were anaesthetized and subjected to sciatic nerve injury model. Rats were then seperated into two groups; one group was treated with progesterone and the other with saline for five time up to 21 days after injury. Both groups were evaluated fuctionally for 21 days and then killed. Sciatic nerves were examined histopathologically. There was no statistically significant difference between these two groups for up to 4 days. But evaluations after 4th day revealed a better improvement in progesterone treatment group. Our data indicate that progesterone has a beneficial effect in peripheral nerve injury.