Experimental Evaluation of Repair Process of Burn Wound Treated with Aqueous Extract of Achillea millefolium on Animal Model: Clinical and Histopathological Study

This study was performed to evaluate the accelerating effect of aqueous extract of yarrow on the burn wound healing in an animal model. Ten male adult white Dutch rabbits, with mean weight of 2,000±250 g were studied. Burn wounds were created in dorsal region of each animal, according to Hoekstra model. The experiment wounds were treated with 5 mL of aqueous extracts of yarrow every day. The control wounds were only washed with the same amount of normal saline. The wounds were photographed and compared for rate of wound contraction with digital scanning software. Specimens were taken for histopathological examinations on day 21. Significant differences were seen between the experiment and control wounds for the rate of contraction. On histopathological evaluation granulation and epithelization were more pronounced and the collagen fibers were also more orderly arranged in the experiment group. It is concluded that topical application of aqueous yarrow extract, as used in this study could improve rate of burn wound healing in the rabbit.