Effect of Oral Administration of Ethanolic Leaf Extract of Acanthospermum Hispidum Dc on Carbon Tetrachloride Induced Acute Liver Injury in Rats

The effects of administering Acanthospermum hispidum dc ethanolic leaf extract on patients of hepatitis were studied on acute hepatitis induced by carbon tetrachloride (20% CCl4/olive oil, 1.5 ml/kg, p.o) in rats. The effects were monitored by estimating the serum transaminases levels and the histopathological changes in the livers of experimental rats. The pretreatment of the animals with Acanthospermum hispidum dc leaf extract (0.3 2.0 g/kg orally) significantly elevated the activities of the serum transaminases as well as the hepathotoxin induced histopathological changes in the livers of the experimental rats. But in cases of no hepatitis the observed effect of the leaf extract was normal like that of the control.