Effect of Ceftriaxone on Isolated Gastrointestinal Muscles

The pharmacodynamic effect of ceftriaxone on smooth muscles was investigated in isolated organs. Maximum stimulation of isolated guinea pig s ileum and rabbit s duodenum and rat s fundic strip was achieved by addition of 1024 μg of ceftriaxone mL-1 bath. While in isolated rat s colon, it was achieved by 512 μg of ceftriaxone mL-1 bath. Trials were performed to locate the site of action of ceftriaxone on the guinea pig s ileum, rabbit s duodenum and rat s colon. After blocking the ganglia with large dose of nicotine and addition of atropine sulphate as muscarinic cholinergic receptor blocker, ceftriaxone was able to produce its stimulatory effect. Adrenaline was able to produce its inhibitory effect in presence of ceftriaxone. The above mentioned trials indicated that ceftriaxone might have a direct stimulatory effect on the ileal, duodenal and colon smooth muscles. Ceftriaxone in concentration of 1024 μg mL-1 bath has a serotonin like effect on rat s fundic strip.